If AME is of use to you in your research, please cite:
Robert McLeay and Timothy L. Bailey, "Motif Enrichment Analysis: A unified framework and method evaluation", BMC Bioinformatics, 11:165, 2010, doi:10.1186/1471-2105-11-165.
ame --oc results/mea_results_ame/cMyc.ame_out --verbose 1 --fix-partition 3422 --bgformat 0 data/chipseq_databases/Chen_ChIP_seq_datasets//mm8_cMyc_ESC_chen-shuffled_w_bg.fasta data/motif_databases/all_vertebrates.meme
Not in partition maximisation mode. Fixing partition at 3422.
Threshold p-value for reporting results: 0.001
Motif p-values are corrected by #Motifs × #ThresholdsTested – (532 × 1 = 532)
motif number | scoring method | motif name | secondary motif name | scored sequences | p-value | corrected p-value |
---|---|---|---|---|---|---|
1. | Fisher-exact test | MA0093.1 | USF1 | top 3422 seqs | 7.217e-208 | 3.84e-205 |
2. | Fisher-exact test | MA0004.1 | Arnt | top 3422 seqs | 7.217e-208 | 3.84e-205 |
3. | Fisher-exact test | MA0104.1 | Mycn | top 3422 seqs | 7.217e-208 | 3.84e-205 |
4. | Fisher-exact test | MA0104.2 | Mycn | top 3422 seqs | 4.478e-188 | 2.383e-185 |
5. | Fisher-exact test | UP00060_1 | Max_primary | top 3422 seqs | 4.6e-178 | 2.447e-175 |
6. | Fisher-exact test | MA0147.1 | Myc | top 3422 seqs | 1.199e-177 | 6.38e-175 |
7. | Fisher-exact test | MA0059.1 | MYC::MAX | top 3422 seqs | 5.3e-165 | 2.819e-162 |
8. | Fisher-exact test | MA0058.1 | MAX | top 3422 seqs | 8.572e-146 | 4.56e-143 |
9. | Fisher-exact test | UP00050_2 | Bhlhb2_secondary | top 3422 seqs | 2.371e-64 | 1.261e-61 |
10. | Fisher-exact test | UP00015_1 | Ehf_primary | top 3422 seqs | 3.336e-61 | 1.775e-58 |
11. | Fisher-exact test | UP00407_1 | Elf3_primary | top 3422 seqs | 1.383e-60 | 7.359e-58 |
12. | Fisher-exact test | MA0259.1 | HIF1A::ARNT | top 3422 seqs | 1.835e-58 | 9.764e-56 |
13. | Fisher-exact test | MA0039.2 | Klf4 | top 3422 seqs | 4.393e-57 | 2.337e-54 |
14. | Fisher-exact test | MA0149.1 | EWSR1-FLI1 | top 3422 seqs | 2.4e-55 | 1.277e-52 |
15. | Fisher-exact test | UP00093_1 | Klf7_primary | top 3422 seqs | 3.959e-55 | 2.106e-52 |
16. | Fisher-exact test | UP00024_1 | Glis2_primary | top 3422 seqs | 4.331e-55 | 2.304e-52 |
17. | Fisher-exact test | UP00047_1 | Zbtb7b_primary | top 3422 seqs | 1.249e-53 | 6.646e-51 |
18. | Fisher-exact test | UP00050_1 | Bhlhb2_primary | top 3422 seqs | 1.185e-52 | 6.304e-50 |
19. | Fisher-exact test | UP00021_2 | Zfp281_secondary | top 3422 seqs | 1.734e-52 | 9.223e-50 |
20. | Fisher-exact test | UP00022_2 | Zfp740_secondary | top 3422 seqs | 2.616e-50 | 1.391e-47 |
21. | Fisher-exact test | MA0156.1 | FEV | top 3422 seqs | 3.386e-47 | 1.801e-44 |
22. | Fisher-exact test | UP00408_1 | Gabpa_primary | top 3422 seqs | 8.538e-44 | 4.542e-41 |
23. | Fisher-exact test | UP00099_2 | Ascl2_secondary | top 3422 seqs | 4.279e-42 | 2.276e-39 |
24. | Fisher-exact test | MA0062.2 | GABPA | top 3422 seqs | 7.782e-41 | 4.14e-38 |
25. | Fisher-exact test | MA0136.1 | ELF5 | top 3422 seqs | 5.59e-39 | 2.974e-36 |
26. | Fisher-exact test | MA0073.1 | RREB1 | top 3422 seqs | 7.195e-37 | 3.828e-34 |
27. | Fisher-exact test | UP00097_2 | Mtf1_secondary | top 3422 seqs | 9.036e-36 | 4.807e-33 |
28. | Fisher-exact test | UP00002_1 | Sp4_primary | top 3422 seqs | 1.631e-32 | 8.674e-30 |
29. | Fisher-exact test | UP00000_2 | Smad3_secondary | top 3422 seqs | 5.088e-31 | 2.707e-28 |
30. | Fisher-exact test | UP00077_2 | Srf_secondary | top 3422 seqs | 1.31e-30 | 6.969e-28 |
31. | Fisher-exact test | UP00037_1 | Zfp105_primary | top 3422 seqs | 1.938e-30 | 1.031e-27 |
32. | Fisher-exact test | MA0079.2 | SP1 | top 3422 seqs | 2.111e-30 | 1.123e-27 |
33. | Fisher-exact test | UP00033_2 | Zfp410_secondary | top 3422 seqs | 2.122e-30 | 1.129e-27 |
34. | Fisher-exact test | UP00085_1 | Sfpi1_primary | top 3422 seqs | 2.611e-30 | 1.389e-27 |
35. | Fisher-exact test | UP00406_1 | Spdef_primary | top 3422 seqs | 9.734e-30 | 5.178e-27 |
36. | Fisher-exact test | UP00046_1 | Tcfe2a_primary | top 3422 seqs | 6.909e-27 | 3.676e-24 |
37. | Fisher-exact test | MA0062.1 | GABPA | top 3422 seqs | 2.967e-26 | 1.579e-23 |
38. | Fisher-exact test | MA0076.1 | ELK4 | top 3422 seqs | 5.254e-26 | 2.795e-23 |
39. | Fisher-exact test | UP00088_2 | Plagl1_secondary | top 3422 seqs | 7.389e-26 | 3.931e-23 |
40. | Fisher-exact test | UP00408_2 | Gabpa_secondary | top 3422 seqs | 9.517e-26 | 5.063e-23 |
41. | Fisher-exact test | UP00043_2 | Bcl6b_secondary | top 3422 seqs | 1.295e-25 | 6.89e-23 |
42. | Fisher-exact test | MA0039.1 | Klf4 | top 3422 seqs | 3.973e-25 | 2.114e-22 |
43. | Fisher-exact test | UP00021_1 | Zfp281_primary | top 3422 seqs | 9.269e-25 | 4.931e-22 |
44. | Fisher-exact test | MA0162.1 | Egr1 | top 3422 seqs | 1.203e-24 | 6.402e-22 |
45. | Fisher-exact test | MA0105.1 | NFKB1 | top 3422 seqs | 3.792e-24 | 2.017e-21 |
46. | Fisher-exact test | UP00103_1 | Jundm2_primary | top 3422 seqs | 9.62e-24 | 5.118e-21 |
47. | Fisher-exact test | UP00096_2 | Sox13_secondary | top 3422 seqs | 1.922e-22 | 1.022e-19 |
48. | Fisher-exact test | UP00060_2 | Max_secondary | top 3422 seqs | 4.726e-21 | 2.514e-18 |
49. | Fisher-exact test | UP00061_1 | Foxl1_primary | top 3422 seqs | 5.809e-21 | 3.09e-18 |
50. | Fisher-exact test | MA0100.1 | Myb | top 3422 seqs | 6.523e-20 | 3.47e-17 |
51. | Fisher-exact test | UP00020_1 | Atf1_primary | top 3422 seqs | 7.734e-20 | 4.115e-17 |
52. | Fisher-exact test | UP00088_1 | Plagl1_primary | top 3422 seqs | 2.124e-19 | 1.13e-16 |
53. | Fisher-exact test | MA0137.1 | STAT1 | top 3422 seqs | 5.6e-19 | 2.979e-16 |
54. | Fisher-exact test | MA0152.1 | NFATC2 | top 3422 seqs | 1.136e-18 | 6.043e-16 |
55. | Fisher-exact test | UP00407_2 | Elf3_secondary | top 3422 seqs | 1.279e-18 | 6.805e-16 |
56. | Fisher-exact test | MA0116.1 | Zfp423 | top 3422 seqs | 2.5e-18 | 1.33e-15 |
57. | Fisher-exact test | UP00030_1 | Sox11_primary | top 3422 seqs | 2.997e-18 | 1.594e-15 |
58. | Fisher-exact test | UP00035_2 | Hic1_secondary | top 3422 seqs | 8.862e-18 | 4.715e-15 |
59. | Fisher-exact test | UP00028_2 | Tcfap2e_secondary | top 3422 seqs | 1.308e-17 | 6.957e-15 |
60. | Fisher-exact test | MA0137.2 | STAT1 | top 3422 seqs | 3.48e-17 | 1.852e-14 |
61. | Fisher-exact test | UP00061_2 | Foxl1_secondary | top 3422 seqs | 7.543e-17 | 4.013e-14 |
62. | Fisher-exact test | UP00062_1 | Sox4_primary | top 3422 seqs | 1.246e-16 | 6.627e-14 |
63. | Fisher-exact test | UP00073_1 | Foxa2_primary | top 3422 seqs | 3.206e-16 | 1.706e-13 |
64. | Fisher-exact test | UP00025_1 | Foxk1_primary | top 3422 seqs | 6.348e-16 | 3.377e-13 |
65. | Fisher-exact test | UP00029_1 | Tbp_primary | top 3422 seqs | 7.574e-16 | 4.029e-13 |
66. | Fisher-exact test | MA0028.1 | ELK1 | top 3422 seqs | 1.06e-15 | 5.642e-13 |
67. | Fisher-exact test | MA0050.1 | IRF1 | top 3422 seqs | 1.375e-14 | 7.316e-12 |
68. | Fisher-exact test | UP00039_1 | Foxj3_primary | top 3422 seqs | 5.87e-14 | 3.123e-11 |
69. | Fisher-exact test | MA0144.1 | Stat3 | top 3422 seqs | 6.302e-14 | 3.353e-11 |
70. | Fisher-exact test | MA0081.1 | SPIB | top 3422 seqs | 6.473e-14 | 3.444e-11 |
71. | Fisher-exact test | MA0041.1 | Foxd3 | top 3422 seqs | 7.093e-14 | 3.773e-11 |
72. | Fisher-exact test | MA0080.1 | SPI1 | top 3422 seqs | 1.335e-13 | 7.103e-11 |
73. | Fisher-exact test | MA0098.1 | ETS1 | top 3422 seqs | 1.335e-13 | 7.103e-11 |
74. | Fisher-exact test | UP00065_1 | Zfp161_primary | top 3422 seqs | 2.302e-13 | 1.225e-10 |
75. | Fisher-exact test | MA0088.1 | znf143 | top 3422 seqs | 1.154e-12 | 6.14e-10 |
76. | Fisher-exact test | UP00101_2 | Sox12_secondary | top 3422 seqs | 3.719e-12 | 1.979e-09 |
77. | Fisher-exact test | MA0025.1 | NFIL3 | top 3422 seqs | 4.103e-12 | 2.183e-09 |
78. | Fisher-exact test | UP00244_1 | Tlx2_3498.2 | top 3422 seqs | 7.262e-12 | 3.863e-09 |
79. | Fisher-exact test | MA0042.1 | FOXI1 | top 3422 seqs | 8.87e-12 | 4.719e-09 |
80. | Fisher-exact test | UP00041_1 | Foxj1_primary | top 3422 seqs | 1.03e-11 | 5.482e-09 |
81. | Fisher-exact test | MA0119.1 | TLX1::NFIC | top 3422 seqs | 4.921e-11 | 2.618e-08 |
82. | Fisher-exact test | MA0055.1 | Myf | top 3422 seqs | 5.391e-11 | 2.868e-08 |
83. | Fisher-exact test | MA0080.2 | SPI1 | top 3422 seqs | 1.594e-10 | 8.482e-08 |
84. | Fisher-exact test | UP00035_1 | Hic1_primary | top 3422 seqs | 1.701e-10 | 9.048e-08 |
85. | Fisher-exact test | UP00042_2 | Gm397_secondary | top 3422 seqs | 2.187e-10 | 1.163e-07 |
86. | Fisher-exact test | UP00092_2 | Myb_secondary | top 3422 seqs | 2.5e-10 | 1.33e-07 |
87. | Fisher-exact test | UP00049_2 | Sp100_secondary | top 3422 seqs | 3.112e-10 | 1.656e-07 |
88. | Fisher-exact test | UP00087_1 | Tcfap2c_primary | top 3422 seqs | 5.856e-10 | 3.115e-07 |
89. | Fisher-exact test | UP00002_2 | Sp4_secondary | top 3422 seqs | 7.452e-10 | 3.964e-07 |
90. | Fisher-exact test | UP00255_1 | Dbx1_3486.1 | top 3422 seqs | 9.747e-10 | 5.185e-07 |
91. | Fisher-exact test | UP00179_1 | Pou2f3_3986.2 | top 3422 seqs | 1.37e-09 | 7.288e-07 |
92. | Fisher-exact test | UP00191_1 | Pou2f2_3748.1 | top 3422 seqs | 1.56e-09 | 8.297e-07 |
93. | Fisher-exact test | MA0148.1 | FOXA1 | top 3422 seqs | 1.651e-09 | 8.782e-07 |
94. | Fisher-exact test | UP00057_1 | Zic2_primary | top 3422 seqs | 1.668e-09 | 8.875e-07 |
95. | Fisher-exact test | MA0030.1 | FOXF2 | top 3422 seqs | 1.785e-09 | 9.498e-07 |
96. | Fisher-exact test | MA0079.1 | SP1 | top 3422 seqs | 1.929e-09 | 1.026e-06 |
97. | Fisher-exact test | UP00047_2 | Zbtb7b_secondary | top 3422 seqs | 2.008e-09 | 1.068e-06 |
98. | Fisher-exact test | UP00007_1 | Egr1_primary | top 3422 seqs | 2.277e-09 | 1.211e-06 |
99. | Fisher-exact test | UP00005_1 | Tcfap2a_primary | top 3422 seqs | 2.713e-09 | 1.443e-06 |
100. | Fisher-exact test | MA0154.1 | EBF1 | top 3422 seqs | 4.041e-09 | 2.15e-06 |
101. | Fisher-exact test | UP00010_1 | Tcfap2b_primary | top 3422 seqs | 4.344e-09 | 2.311e-06 |
102. | Fisher-exact test | MA0061.1 | NF-kappaB | top 3422 seqs | 4.365e-09 | 2.322e-06 |
103. | Fisher-exact test | MA0130.1 | ZNF354C | top 3422 seqs | 4.747e-09 | 2.525e-06 |
104. | Fisher-exact test | MA0068.1 | Pax4 | top 3422 seqs | 1.802e-08 | 9.589e-06 |
105. | Fisher-exact test | MA0002.2 | RUNX1 | top 3422 seqs | 3.757e-08 | 1.999e-05 |
106. | Fisher-exact test | MA0060.1 | NFYA | top 3422 seqs | 3.959e-08 | 2.106e-05 |
107. | Fisher-exact test | UP00081_2 | Mybl1_secondary | top 3422 seqs | 4.103e-08 | 2.183e-05 |
108. | Fisher-exact test | MA0043.1 | HLF | top 3422 seqs | 4.918e-08 | 2.616e-05 |
109. | Fisher-exact test | UP00006_1 | Zic3_primary | top 3422 seqs | 5.282e-08 | 2.81e-05 |
110. | Fisher-exact test | UP00188_1 | Lmx1a_2238.2 | top 3422 seqs | 6.372e-08 | 3.39e-05 |
111. | Fisher-exact test | UP00102_1 | Zic1_primary | top 3422 seqs | 7.925e-08 | 4.216e-05 |
112. | Fisher-exact test | UP00099_1 | Ascl2_primary | top 3422 seqs | 8.313e-08 | 4.422e-05 |
113. | Fisher-exact test | UP00086_1 | Irf3_primary | top 3422 seqs | 1.757e-07 | 9.345e-05 |
114. | Fisher-exact test | UP00073_2 | Foxa2_secondary | top 3422 seqs | 2.83e-07 | 0.0001505 |
115. | Fisher-exact test | UP00024_2 | Glis2_secondary | top 3422 seqs | 3.8e-07 | 0.0002021 |
116. | Fisher-exact test | MA0157.1 | FOXO3 | top 3422 seqs | 4.427e-07 | 0.0002355 |
117. | Fisher-exact test | UP00097_1 | Mtf1_primary | top 3422 seqs | 7.159e-07 | 0.0003808 |
118. | Fisher-exact test | MA0047.2 | Foxa2 | top 3422 seqs | 7.813e-07 | 0.0004156 |
119. | Fisher-exact test | MA0051.1 | IRF2 | top 3422 seqs | 7.893e-07 | 0.0004198 |
120. | Fisher-exact test | UP00076_2 | Rfxdc2_secondary | top 3422 seqs | 7.987e-07 | 0.0004248 |
121. | Fisher-exact test | UP00070_2 | Gcm1_secondary | top 3422 seqs | 8.839e-07 | 0.0004701 |
122. | Fisher-exact test | UP00231_1 | Nkx2-2_2823.1 | top 3422 seqs | 9.972e-07 | 0.0005304 |
123. | Fisher-exact test | UP00169_1 | Lmx1b_3433.2 | top 3422 seqs | 1.323e-06 | 0.0007036 |
124. | Fisher-exact test | UP00168_1 | Hoxd8_2644.1 | top 3422 seqs | 1.462e-06 | 0.0007773 |