If AME is of use to you in your research, please cite:
Robert McLeay and Timothy L. Bailey, "Motif Enrichment Analysis: A unified framework and method evaluation", BMC Bioinformatics, 11:165, 2010, doi:10.1186/1471-2105-11-165.
ame --oc results/mea_results_ame/Smad1.ame_out --verbose 1 --fix-partition 1126 --bgformat 0 data/chipseq_databases/Chen_ChIP_seq_datasets//mm8_Smad1_ESC_chen-shuffled_w_bg.fasta data/motif_databases/all_vertebrates.meme
Not in partition maximisation mode. Fixing partition at 1126.
Threshold p-value for reporting results: 0.001
Motif p-values are corrected by #Motifs × #ThresholdsTested – (532 × 1 = 532)
motif number | scoring method | motif name | secondary motif name | scored sequences | p-value | corrected p-value |
---|---|---|---|---|---|---|
1. | Fisher-exact test | MA0142.1 | Pou5f1 | top 1126 seqs | 1.088e-58 | 5.788e-56 |
2. | Fisher-exact test | MA0143.1 | Sox2 | top 1126 seqs | 3.322e-47 | 1.767e-44 |
3. | Fisher-exact test | MA0039.2 | Klf4 | top 1126 seqs | 1.99e-28 | 1.059e-25 |
4. | Fisher-exact test | UP00062_1 | Sox4_primary | top 1126 seqs | 1.99e-26 | 1.058e-23 |
5. | Fisher-exact test | UP00030_1 | Sox11_primary | top 1126 seqs | 3.187e-26 | 1.696e-23 |
6. | Fisher-exact test | UP00191_1 | Pou2f2_3748.1 | top 1126 seqs | 4.43e-24 | 2.357e-21 |
7. | Fisher-exact test | UP00179_1 | Pou2f3_3986.2 | top 1126 seqs | 4.43e-24 | 2.357e-21 |
8. | Fisher-exact test | UP00093_1 | Klf7_primary | top 1126 seqs | 1.209e-21 | 6.432e-19 |
9. | Fisher-exact test | MA0079.2 | SP1 | top 1126 seqs | 5.412e-21 | 2.879e-18 |
10. | Fisher-exact test | UP00102_2 | Zic1_secondary | top 1126 seqs | 3.866e-19 | 2.057e-16 |
11. | Fisher-exact test | UP00006_2 | Zic3_secondary | top 1126 seqs | 4.724e-19 | 2.513e-16 |
12. | Fisher-exact test | UP00057_2 | Zic2_secondary | top 1126 seqs | 5.71e-19 | 3.038e-16 |
13. | Fisher-exact test | UP00099_2 | Ascl2_secondary | top 1126 seqs | 8.863e-18 | 4.715e-15 |
14. | Fisher-exact test | UP00021_1 | Zfp281_primary | top 1126 seqs | 8.99e-18 | 4.783e-15 |
15. | Fisher-exact test | UP00034_1 | Sox7_primary | top 1126 seqs | 3.904e-17 | 2.077e-14 |
16. | Fisher-exact test | UP00023_1 | Sox30_primary | top 1126 seqs | 1.032e-16 | 5.488e-14 |
17. | Fisher-exact test | UP00002_1 | Sp4_primary | top 1126 seqs | 7.26e-16 | 3.862e-13 |
18. | Fisher-exact test | UP00043_2 | Bcl6b_secondary | top 1126 seqs | 1.378e-15 | 7.331e-13 |
19. | Fisher-exact test | MA0073.1 | RREB1 | top 1126 seqs | 1.684e-15 | 8.961e-13 |
20. | Fisher-exact test | UP00061_1 | Foxl1_primary | top 1126 seqs | 1.567e-14 | 8.335e-12 |
21. | Fisher-exact test | UP00101_2 | Sox12_secondary | top 1126 seqs | 7.403e-14 | 3.938e-11 |
22. | Fisher-exact test | UP00101_1 | Sox12_primary | top 1126 seqs | 1.017e-13 | 5.413e-11 |
23. | Fisher-exact test | UP00004_2 | Sox14_secondary | top 1126 seqs | 3.885e-13 | 2.067e-10 |
24. | Fisher-exact test | MA0162.1 | Egr1 | top 1126 seqs | 8.149e-13 | 4.335e-10 |
25. | Fisher-exact test | MA0084.1 | SRY | top 1126 seqs | 1.291e-12 | 6.868e-10 |
26. | Fisher-exact test | UP00033_2 | Zfp410_secondary | top 1126 seqs | 1.622e-12 | 8.627e-10 |
27. | Fisher-exact test | MA0079.1 | SP1 | top 1126 seqs | 7.198e-12 | 3.829e-09 |
28. | Fisher-exact test | UP00000_2 | Smad3_secondary | top 1126 seqs | 1.992e-11 | 1.06e-08 |
29. | Fisher-exact test | MA0062.1 | GABPA | top 1126 seqs | 2.117e-11 | 1.126e-08 |
30. | Fisher-exact test | UP00211_1 | Pou3f3_3235.2 | top 1126 seqs | 2.528e-11 | 1.345e-08 |
31. | Fisher-exact test | MA0077.1 | SOX9 | top 1126 seqs | 3.384e-11 | 1.801e-08 |
32. | Fisher-exact test | UP00021_2 | Zfp281_secondary | top 1126 seqs | 4.728e-11 | 2.515e-08 |
33. | Fisher-exact test | UP00096_2 | Sox13_secondary | top 1126 seqs | 2.465e-10 | 1.311e-07 |
34. | Fisher-exact test | UP00061_2 | Foxl1_secondary | top 1126 seqs | 2.896e-10 | 1.541e-07 |
35. | Fisher-exact test | UP00097_2 | Mtf1_secondary | top 1126 seqs | 3.045e-10 | 1.62e-07 |
36. | Fisher-exact test | UP00408_2 | Gabpa_secondary | top 1126 seqs | 5.247e-10 | 2.791e-07 |
37. | Fisher-exact test | UP00047_1 | Zbtb7b_primary | top 1126 seqs | 5.27e-10 | 2.804e-07 |
38. | Fisher-exact test | MA0078.1 | Sox17 | top 1126 seqs | 5.714e-10 | 3.04e-07 |
39. | Fisher-exact test | MA0042.1 | FOXI1 | top 1126 seqs | 7.271e-10 | 3.868e-07 |
40. | Fisher-exact test | UP00099_1 | Ascl2_primary | top 1126 seqs | 1.459e-09 | 7.76e-07 |
41. | Fisher-exact test | MA0149.1 | EWSR1-FLI1 | top 1126 seqs | 1.933e-09 | 1.029e-06 |
42. | Fisher-exact test | UP00073_1 | Foxa2_primary | top 1126 seqs | 2.066e-09 | 1.099e-06 |
43. | Fisher-exact test | UP00042_2 | Gm397_secondary | top 1126 seqs | 5.593e-09 | 2.975e-06 |
44. | Fisher-exact test | MA0060.1 | NFYA | top 1126 seqs | 2.039e-08 | 1.085e-05 |
45. | Fisher-exact test | UP00037_1 | Zfp105_primary | top 1126 seqs | 2.073e-08 | 1.103e-05 |
46. | Fisher-exact test | MA0030.1 | FOXF2 | top 1126 seqs | 3.078e-08 | 1.638e-05 |
47. | Fisher-exact test | UP00075_1 | Sox15_primary | top 1126 seqs | 3.231e-08 | 1.719e-05 |
48. | Fisher-exact test | UP00046_1 | Tcfe2a_primary | top 1126 seqs | 3.242e-08 | 1.725e-05 |
49. | Fisher-exact test | UP00025_1 | Foxk1_primary | top 1126 seqs | 3.489e-08 | 1.856e-05 |
50. | Fisher-exact test | UP00079_1 | Esrra_primary | top 1126 seqs | 3.532e-08 | 1.879e-05 |
51. | Fisher-exact test | UP00016_2 | Sry_secondary | top 1126 seqs | 3.729e-08 | 1.984e-05 |
52. | Fisher-exact test | UP00041_1 | Foxj1_primary | top 1126 seqs | 4.365e-08 | 2.322e-05 |
53. | Fisher-exact test | UP00408_1 | Gabpa_primary | top 1126 seqs | 4.366e-08 | 2.323e-05 |
54. | Fisher-exact test | MA0062.2 | GABPA | top 1126 seqs | 4.99e-08 | 2.655e-05 |
55. | Fisher-exact test | MA0039.1 | Klf4 | top 1126 seqs | 6.63e-08 | 3.527e-05 |
56. | Fisher-exact test | UP00064_1 | Sox18_primary | top 1126 seqs | 7.436e-08 | 3.956e-05 |
57. | Fisher-exact test | MA0004.1 | Arnt | top 1126 seqs | 7.562e-08 | 4.023e-05 |
58. | Fisher-exact test | MA0093.1 | USF1 | top 1126 seqs | 7.562e-08 | 4.023e-05 |
59. | Fisher-exact test | MA0104.1 | Mycn | top 1126 seqs | 7.562e-08 | 4.023e-05 |
60. | Fisher-exact test | UP00255_1 | Dbx1_3486.1 | top 1126 seqs | 1.088e-07 | 5.786e-05 |
61. | Fisher-exact test | MA0144.1 | Stat3 | top 1126 seqs | 1.362e-07 | 7.243e-05 |
62. | Fisher-exact test | UP00022_1 | Zfp740_primary | top 1126 seqs | 1.43e-07 | 7.607e-05 |
63. | Fisher-exact test | UP00039_1 | Foxj3_primary | top 1126 seqs | 1.915e-07 | 0.0001019 |
64. | Fisher-exact test | MA0141.1 | Esrrb | top 1126 seqs | 2.092e-07 | 0.0001113 |
65. | Fisher-exact test | MA0137.2 | STAT1 | top 1126 seqs | 2.626e-07 | 0.0001397 |
66. | Fisher-exact test | MA0069.1 | Pax6 | top 1126 seqs | 3.363e-07 | 0.0001789 |