If AME is of use to you in your research, please cite:
Robert McLeay and Timothy L. Bailey, "Motif Enrichment Analysis: A unified framework and method evaluation", BMC Bioinformatics, 11:165, 2010, doi:10.1186/1471-2105-11-165.
ame --oc results/mea_results_ame/STAT3.ame_out --verbose 1 --fix-partition 2546 --bgformat 0 data/chipseq_databases/Chen_ChIP_seq_datasets//mm8_STAT3_ESC_chen-shuffled_w_bg.fasta data/motif_databases/all_vertebrates.meme
Not in partition maximisation mode. Fixing partition at 2546.
Threshold p-value for reporting results: 0.001
Motif p-values are corrected by #Motifs × #ThresholdsTested – (532 × 1 = 532)
motif number | scoring method | motif name | secondary motif name | scored sequences | p-value | corrected p-value |
---|---|---|---|---|---|---|
1. | Fisher-exact test | MA0137.2 | STAT1 | top 2546 seqs | 1.259e-122 | 6.697e-120 |
2. | Fisher-exact test | MA0144.1 | Stat3 | top 2546 seqs | 1.205e-108 | 6.41e-106 |
3. | Fisher-exact test | MA0039.2 | Klf4 | top 2546 seqs | 3.278e-63 | 1.744e-60 |
4. | Fisher-exact test | UP00093_1 | Klf7_primary | top 2546 seqs | 3.256e-58 | 1.732e-55 |
5. | Fisher-exact test | UP00002_1 | Sp4_primary | top 2546 seqs | 1.152e-40 | 6.127e-38 |
6. | Fisher-exact test | UP00099_2 | Ascl2_secondary | top 2546 seqs | 7.199e-40 | 3.83e-37 |
7. | Fisher-exact test | UP00021_2 | Zfp281_secondary | top 2546 seqs | 3.576e-39 | 1.903e-36 |
8. | Fisher-exact test | MA0073.1 | RREB1 | top 2546 seqs | 5.488e-35 | 2.92e-32 |
9. | Fisher-exact test | MA0149.1 | EWSR1-FLI1 | top 2546 seqs | 2.735e-34 | 1.455e-31 |
10. | Fisher-exact test | MA0142.1 | Pou5f1 | top 2546 seqs | 2.653e-33 | 1.411e-30 |
11. | Fisher-exact test | MA0079.2 | SP1 | top 2546 seqs | 7.49e-31 | 3.985e-28 |
12. | Fisher-exact test | UP00047_1 | Zbtb7b_primary | top 2546 seqs | 1.767e-30 | 9.399e-28 |
13. | Fisher-exact test | UP00000_2 | Smad3_secondary | top 2546 seqs | 5.719e-30 | 3.043e-27 |
14. | Fisher-exact test | MA0143.1 | Sox2 | top 2546 seqs | 1.358e-29 | 7.227e-27 |
15. | Fisher-exact test | MA0062.2 | GABPA | top 2546 seqs | 1.823e-29 | 9.699e-27 |
16. | Fisher-exact test | UP00021_1 | Zfp281_primary | top 2546 seqs | 6.67e-29 | 3.548e-26 |
17. | Fisher-exact test | UP00022_2 | Zfp740_secondary | top 2546 seqs | 9.212e-29 | 4.901e-26 |
18. | Fisher-exact test | MA0162.1 | Egr1 | top 2546 seqs | 3.273e-28 | 1.741e-25 |
19. | Fisher-exact test | UP00015_1 | Ehf_primary | top 2546 seqs | 3.404e-28 | 1.811e-25 |
20. | Fisher-exact test | UP00407_1 | Elf3_primary | top 2546 seqs | 7.3e-28 | 3.884e-25 |
21. | Fisher-exact test | UP00033_2 | Zfp410_secondary | top 2546 seqs | 1.191e-27 | 6.338e-25 |
22. | Fisher-exact test | MA0156.1 | FEV | top 2546 seqs | 3.166e-26 | 1.685e-23 |
23. | Fisher-exact test | UP00043_2 | Bcl6b_secondary | top 2546 seqs | 1.3e-25 | 6.914e-23 |
24. | Fisher-exact test | UP00408_2 | Gabpa_secondary | top 2546 seqs | 5.451e-24 | 2.9e-21 |
25. | Fisher-exact test | UP00024_1 | Glis2_primary | top 2546 seqs | 9.567e-24 | 5.089e-21 |
26. | Fisher-exact test | UP00062_1 | Sox4_primary | top 2546 seqs | 5.615e-23 | 2.987e-20 |
27. | Fisher-exact test | UP00191_1 | Pou2f2_3748.1 | top 2546 seqs | 7.356e-22 | 3.913e-19 |
28. | Fisher-exact test | MA0068.1 | Pax4 | top 2546 seqs | 1.622e-21 | 8.63e-19 |
29. | Fisher-exact test | UP00030_1 | Sox11_primary | top 2546 seqs | 2.37e-21 | 1.261e-18 |
30. | Fisher-exact test | UP00007_1 | Egr1_primary | top 2546 seqs | 7.388e-21 | 3.93e-18 |
31. | Fisher-exact test | UP00073_1 | Foxa2_primary | top 2546 seqs | 2.558e-19 | 1.361e-16 |
32. | Fisher-exact test | UP00179_1 | Pou2f3_3986.2 | top 2546 seqs | 4.472e-19 | 2.379e-16 |
33. | Fisher-exact test | MA0079.1 | SP1 | top 2546 seqs | 1.111e-18 | 5.91e-16 |
34. | Fisher-exact test | MA0062.1 | GABPA | top 2546 seqs | 2.425e-18 | 1.29e-15 |
35. | Fisher-exact test | UP00025_1 | Foxk1_primary | top 2546 seqs | 2.713e-18 | 1.443e-15 |
36. | Fisher-exact test | MA0039.1 | Klf4 | top 2546 seqs | 3.807e-17 | 2.025e-14 |
37. | Fisher-exact test | UP00061_1 | Foxl1_primary | top 2546 seqs | 4.223e-17 | 2.247e-14 |
38. | Fisher-exact test | UP00043_1 | Bcl6b_primary | top 2546 seqs | 2.106e-16 | 1.12e-13 |
39. | Fisher-exact test | UP00408_1 | Gabpa_primary | top 2546 seqs | 6.624e-16 | 3.524e-13 |
40. | Fisher-exact test | MA0041.1 | Foxd3 | top 2546 seqs | 8.798e-16 | 4.681e-13 |
41. | Fisher-exact test | UP00077_2 | Srf_secondary | top 2546 seqs | 1.461e-15 | 7.77e-13 |
42. | Fisher-exact test | UP00101_2 | Sox12_secondary | top 2546 seqs | 2.354e-15 | 1.252e-12 |
43. | Fisher-exact test | MA0136.1 | ELF5 | top 2546 seqs | 3.109e-15 | 1.654e-12 |
44. | Fisher-exact test | UP00061_2 | Foxl1_secondary | top 2546 seqs | 3.141e-15 | 1.671e-12 |
45. | Fisher-exact test | MA0076.1 | ELK4 | top 2546 seqs | 8.879e-15 | 4.724e-12 |
46. | Fisher-exact test | UP00088_2 | Plagl1_secondary | top 2546 seqs | 1.202e-14 | 6.397e-12 |
47. | Fisher-exact test | UP00022_1 | Zfp740_primary | top 2546 seqs | 2.594e-14 | 1.38e-11 |
48. | Fisher-exact test | MA0157.1 | FOXO3 | top 2546 seqs | 3.959e-14 | 2.106e-11 |
49. | Fisher-exact test | MA0137.1 | STAT1 | top 2546 seqs | 6.329e-14 | 3.367e-11 |
50. | Fisher-exact test | UP00097_2 | Mtf1_secondary | top 2546 seqs | 6.945e-14 | 3.695e-11 |
51. | Fisher-exact test | UP00039_1 | Foxj3_primary | top 2546 seqs | 8.017e-14 | 4.265e-11 |
52. | Fisher-exact test | UP00041_1 | Foxj1_primary | top 2546 seqs | 1.285e-13 | 6.839e-11 |
53. | Fisher-exact test | UP00073_2 | Foxa2_secondary | top 2546 seqs | 2.521e-13 | 1.341e-10 |
54. | Fisher-exact test | UP00029_1 | Tbp_primary | top 2546 seqs | 2.666e-13 | 1.418e-10 |
55. | Fisher-exact test | MA0047.2 | Foxa2 | top 2546 seqs | 3.283e-13 | 1.747e-10 |
56. | Fisher-exact test | UP00088_1 | Plagl1_primary | top 2546 seqs | 4.232e-13 | 2.251e-10 |
57. | Fisher-exact test | MA0004.1 | Arnt | top 2546 seqs | 5.15e-13 | 2.74e-10 |
58. | Fisher-exact test | MA0104.1 | Mycn | top 2546 seqs | 5.15e-13 | 2.74e-10 |
59. | Fisher-exact test | MA0093.1 | USF1 | top 2546 seqs | 5.15e-13 | 2.74e-10 |
60. | Fisher-exact test | UP00096_2 | Sox13_secondary | top 2546 seqs | 5.936e-13 | 3.158e-10 |
61. | Fisher-exact test | UP00406_1 | Spdef_primary | top 2546 seqs | 7.474e-13 | 3.976e-10 |
62. | Fisher-exact test | MA0084.1 | SRY | top 2546 seqs | 1.301e-12 | 6.924e-10 |
63. | Fisher-exact test | MA0141.1 | Esrrb | top 2546 seqs | 1.575e-12 | 8.378e-10 |
64. | Fisher-exact test | UP00057_2 | Zic2_secondary | top 2546 seqs | 3.504e-12 | 1.864e-09 |
65. | Fisher-exact test | MA0148.1 | FOXA1 | top 2546 seqs | 3.624e-12 | 1.928e-09 |
66. | Fisher-exact test | UP00006_2 | Zic3_secondary | top 2546 seqs | 3.665e-12 | 1.95e-09 |
67. | Fisher-exact test | UP00034_1 | Sox7_primary | top 2546 seqs | 9.474e-12 | 5.04e-09 |
68. | Fisher-exact test | UP00037_1 | Zfp105_primary | top 2546 seqs | 5.101e-11 | 2.714e-08 |
69. | Fisher-exact test | UP00086_1 | Irf3_primary | top 2546 seqs | 7.318e-11 | 3.893e-08 |
70. | Fisher-exact test | MA0105.1 | NFKB1 | top 2546 seqs | 8.496e-11 | 4.52e-08 |
71. | Fisher-exact test | MA0050.1 | IRF1 | top 2546 seqs | 9.508e-11 | 5.058e-08 |
72. | Fisher-exact test | MA0080.2 | SPI1 | top 2546 seqs | 1.095e-10 | 5.825e-08 |
73. | Fisher-exact test | MA0030.1 | FOXF2 | top 2546 seqs | 1.987e-10 | 1.057e-07 |
74. | Fisher-exact test | UP00102_2 | Zic1_secondary | top 2546 seqs | 2.43e-10 | 1.293e-07 |
75. | Fisher-exact test | UP00035_2 | Hic1_secondary | top 2546 seqs | 2.927e-10 | 1.557e-07 |
76. | Fisher-exact test | MA0160.1 | NR4A2 | top 2546 seqs | 3.613e-10 | 1.922e-07 |
77. | Fisher-exact test | MA0042.1 | FOXI1 | top 2546 seqs | 5.517e-10 | 2.935e-07 |
78. | Fisher-exact test | UP00047_2 | Zbtb7b_secondary | top 2546 seqs | 1.447e-09 | 7.697e-07 |
79. | Fisher-exact test | MA0088.1 | znf143 | top 2546 seqs | 1.659e-09 | 8.825e-07 |
80. | Fisher-exact test | UP00074_1 | Isgf3g_primary | top 2546 seqs | 4.242e-09 | 2.257e-06 |
81. | Fisher-exact test | MA0058.1 | MAX | top 2546 seqs | 4.983e-09 | 2.651e-06 |
82. | Fisher-exact test | UP00042_2 | Gm397_secondary | top 2546 seqs | 5.124e-09 | 2.726e-06 |
83. | Fisher-exact test | MA0164.1 | Nr2e3 | top 2546 seqs | 5.578e-09 | 2.968e-06 |
84. | Fisher-exact test | UP00227_1 | Duxl_1286.2 | top 2546 seqs | 8.135e-09 | 4.328e-06 |
85. | Fisher-exact test | MA0055.1 | Myf | top 2546 seqs | 9.243e-09 | 4.917e-06 |
86. | Fisher-exact test | UP00075_1 | Sox15_primary | top 2546 seqs | 9.832e-09 | 5.231e-06 |
87. | Fisher-exact test | UP00101_1 | Sox12_primary | top 2546 seqs | 1.129e-08 | 6.006e-06 |
88. | Fisher-exact test | MA0116.1 | Zfp423 | top 2546 seqs | 1.305e-08 | 6.945e-06 |
89. | Fisher-exact test | UP00051_1 | Sox8_primary | top 2546 seqs | 1.427e-08 | 7.593e-06 |
90. | Fisher-exact test | UP00094_2 | Zfp128_secondary | top 2546 seqs | 4.011e-08 | 2.134e-05 |
91. | Fisher-exact test | UP00099_1 | Ascl2_primary | top 2546 seqs | 4.299e-08 | 2.287e-05 |
92. | Fisher-exact test | UP00255_1 | Dbx1_3486.1 | top 2546 seqs | 8.634e-08 | 4.593e-05 |
93. | Fisher-exact test | MA0048.1 | NHLH1 | top 2546 seqs | 8.739e-08 | 4.649e-05 |
94. | Fisher-exact test | UP00050_1 | Bhlhb2_primary | top 2546 seqs | 2.232e-07 | 0.0001187 |
95. | Fisher-exact test | UP00244_1 | Tlx2_3498.2 | top 2546 seqs | 2.988e-07 | 0.000159 |
96. | Fisher-exact test | UP00054_2 | Tcf7_secondary | top 2546 seqs | 3.622e-07 | 0.0001927 |
97. | Fisher-exact test | UP00035_1 | Hic1_primary | top 2546 seqs | 4.97e-07 | 0.0002644 |
98. | Fisher-exact test | UP00079_1 | Esrra_primary | top 2546 seqs | 6.224e-07 | 0.000331 |
99. | Fisher-exact test | MA0040.1 | Foxq1 | top 2546 seqs | 7.394e-07 | 0.0003933 |
100. | Fisher-exact test | MA0052.1 | MEF2A | top 2546 seqs | 9.66e-07 | 0.0005138 |
101. | Fisher-exact test | MA0077.1 | SOX9 | top 2546 seqs | 1.136e-06 | 0.000604 |
102. | Fisher-exact test | MA0102.2 | CEBPA | top 2546 seqs | 1.157e-06 | 0.0006156 |
103. | Fisher-exact test | UP00217_1 | Hoxa10_2318.1 | top 2546 seqs | 1.186e-06 | 0.0006308 |
104. | Fisher-exact test | UP00231_1 | Nkx2-2_2823.1 | top 2546 seqs | 1.58e-06 | 0.0008402 |
105. | Fisher-exact test | MA0122.1 | Nkx3-2 | top 2546 seqs | 1.677e-06 | 0.0008918 |