If AME is of use to you in your research, please cite:
Robert McLeay and Timothy L. Bailey, "Motif Enrichment Analysis: A unified framework and method evaluation", BMC Bioinformatics, 11:165, 2010, doi:10.1186/1471-2105-11-165.
ame --oc results/mea_results_ame/Oct4.ame_out --verbose 1 --fix-partition 3760 --bgformat 0 data/chipseq_databases/Chen_ChIP_seq_datasets//mm8_Oct4_ESC_chen-shuffled_w_bg.fasta data/motif_databases/all_vertebrates.meme
Not in partition maximisation mode. Fixing partition at 3760.
Threshold p-value for reporting results: 0.001
Motif p-values are corrected by #Motifs × #ThresholdsTested – (532 × 1 = 532)
motif number | scoring method | motif name | secondary motif name | scored sequences | p-value | corrected p-value |
---|---|---|---|---|---|---|
1. | Fisher-exact test | MA0142.1 | Pou5f1 | top 3760 seqs | 1.591e-229 | 8.466e-227 |
2. | Fisher-exact test | MA0143.1 | Sox2 | top 3760 seqs | 5.201e-163 | 2.767e-160 |
3. | Fisher-exact test | UP00179_1 | Pou2f3_3986.2 | top 3760 seqs | 2.754e-133 | 1.465e-130 |
4. | Fisher-exact test | UP00191_1 | Pou2f2_3748.1 | top 3760 seqs | 6.151e-131 | 3.273e-128 |
5. | Fisher-exact test | UP00211_1 | Pou3f3_3235.2 | top 3760 seqs | 1.554e-82 | 8.268e-80 |
6. | Fisher-exact test | UP00030_1 | Sox11_primary | top 3760 seqs | 1.395e-52 | 7.424e-50 |
7. | Fisher-exact test | UP00062_1 | Sox4_primary | top 3760 seqs | 2.934e-52 | 1.561e-49 |
8. | Fisher-exact test | MA0039.2 | Klf4 | top 3760 seqs | 6.464e-50 | 3.439e-47 |
9. | Fisher-exact test | MA0149.1 | EWSR1-FLI1 | top 3760 seqs | 1.335e-47 | 7.1e-45 |
10. | Fisher-exact test | UP00093_1 | Klf7_primary | top 3760 seqs | 9.152e-43 | 4.869e-40 |
11. | Fisher-exact test | MA0079.2 | SP1 | top 3760 seqs | 8.87e-40 | 4.719e-37 |
12. | Fisher-exact test | UP00002_1 | Sp4_primary | top 3760 seqs | 2.001e-37 | 1.064e-34 |
13. | Fisher-exact test | MA0073.1 | RREB1 | top 3760 seqs | 3.045e-37 | 1.62e-34 |
14. | Fisher-exact test | UP00021_2 | Zfp281_secondary | top 3760 seqs | 4.684e-37 | 2.492e-34 |
15. | Fisher-exact test | UP00099_2 | Ascl2_secondary | top 3760 seqs | 7.669e-35 | 4.08e-32 |
16. | Fisher-exact test | UP00033_2 | Zfp410_secondary | top 3760 seqs | 1.366e-34 | 7.268e-32 |
17. | Fisher-exact test | UP00021_1 | Zfp281_primary | top 3760 seqs | 1.175e-30 | 6.252e-28 |
18. | Fisher-exact test | UP00043_2 | Bcl6b_secondary | top 3760 seqs | 1.905e-28 | 1.014e-25 |
19. | Fisher-exact test | UP00015_1 | Ehf_primary | top 3760 seqs | 4.397e-28 | 2.339e-25 |
20. | Fisher-exact test | UP00034_1 | Sox7_primary | top 3760 seqs | 5.129e-28 | 2.729e-25 |
21. | Fisher-exact test | UP00047_1 | Zbtb7b_primary | top 3760 seqs | 7.549e-28 | 4.016e-25 |
22. | Fisher-exact test | UP00408_2 | Gabpa_secondary | top 3760 seqs | 2.29e-27 | 1.219e-24 |
23. | Fisher-exact test | UP00097_2 | Mtf1_secondary | top 3760 seqs | 8.797e-26 | 4.68e-23 |
24. | Fisher-exact test | UP00061_2 | Foxl1_secondary | top 3760 seqs | 2.463e-25 | 1.31e-22 |
25. | Fisher-exact test | UP00061_1 | Foxl1_primary | top 3760 seqs | 3.348e-24 | 1.781e-21 |
26. | Fisher-exact test | MA0162.1 | Egr1 | top 3760 seqs | 1.887e-23 | 1.004e-20 |
27. | Fisher-exact test | UP00037_1 | Zfp105_primary | top 3760 seqs | 1.042e-22 | 5.542e-20 |
28. | Fisher-exact test | UP00088_2 | Plagl1_secondary | top 3760 seqs | 2.493e-22 | 1.326e-19 |
29. | Fisher-exact test | UP00000_2 | Smad3_secondary | top 3760 seqs | 5.53e-22 | 2.942e-19 |
30. | Fisher-exact test | UP00022_2 | Zfp740_secondary | top 3760 seqs | 1.212e-21 | 6.45e-19 |
31. | Fisher-exact test | UP00101_2 | Sox12_secondary | top 3760 seqs | 2.914e-21 | 1.55e-18 |
32. | Fisher-exact test | MA0004.1 | Arnt | top 3760 seqs | 1.652e-20 | 8.787e-18 |
33. | Fisher-exact test | MA0104.1 | Mycn | top 3760 seqs | 1.652e-20 | 8.787e-18 |
34. | Fisher-exact test | MA0093.1 | USF1 | top 3760 seqs | 1.652e-20 | 8.787e-18 |
35. | Fisher-exact test | UP00096_2 | Sox13_secondary | top 3760 seqs | 1.66e-20 | 8.833e-18 |
36. | Fisher-exact test | UP00024_1 | Glis2_primary | top 3760 seqs | 1.666e-20 | 8.865e-18 |
37. | Fisher-exact test | UP00407_1 | Elf3_primary | top 3760 seqs | 3.148e-20 | 1.675e-17 |
38. | Fisher-exact test | UP00101_1 | Sox12_primary | top 3760 seqs | 3.255e-20 | 1.731e-17 |
39. | Fisher-exact test | MA0062.1 | GABPA | top 3760 seqs | 3.708e-20 | 1.973e-17 |
40. | Fisher-exact test | UP00029_1 | Tbp_primary | top 3760 seqs | 1.287e-19 | 6.848e-17 |
41. | Fisher-exact test | MA0148.1 | FOXA1 | top 3760 seqs | 1.572e-19 | 8.362e-17 |
42. | Fisher-exact test | MA0084.1 | SRY | top 3760 seqs | 4.394e-19 | 2.338e-16 |
43. | Fisher-exact test | MA0039.1 | Klf4 | top 3760 seqs | 5.397e-19 | 2.871e-16 |
44. | Fisher-exact test | UP00073_1 | Foxa2_primary | top 3760 seqs | 6.529e-19 | 3.474e-16 |
45. | Fisher-exact test | MA0062.2 | GABPA | top 3760 seqs | 7.179e-19 | 3.819e-16 |
46. | Fisher-exact test | UP00025_1 | Foxk1_primary | top 3760 seqs | 8.861e-18 | 4.714e-15 |
47. | Fisher-exact test | MA0047.2 | Foxa2 | top 3760 seqs | 1.213e-17 | 6.454e-15 |
48. | Fisher-exact test | UP00085_1 | Sfpi1_primary | top 3760 seqs | 3.059e-17 | 1.627e-14 |
49. | Fisher-exact test | MA0079.1 | SP1 | top 3760 seqs | 4.397e-17 | 2.339e-14 |
50. | Fisher-exact test | MA0041.1 | Foxd3 | top 3760 seqs | 4.977e-17 | 2.648e-14 |
51. | Fisher-exact test | UP00039_1 | Foxj3_primary | top 3760 seqs | 5.793e-17 | 3.082e-14 |
52. | Fisher-exact test | MA0137.1 | STAT1 | top 3760 seqs | 8.02e-17 | 4.266e-14 |
53. | Fisher-exact test | UP00077_2 | Srf_secondary | top 3760 seqs | 1.768e-16 | 9.406e-14 |
54. | Fisher-exact test | MA0136.1 | ELF5 | top 3760 seqs | 4.601e-16 | 2.448e-13 |
55. | Fisher-exact test | MA0144.1 | Stat3 | top 3760 seqs | 4.857e-16 | 2.584e-13 |
56. | Fisher-exact test | MA0068.1 | Pax4 | top 3760 seqs | 7.759e-16 | 4.128e-13 |
57. | Fisher-exact test | UP00035_2 | Hic1_secondary | top 3760 seqs | 1.522e-15 | 8.099e-13 |
58. | Fisher-exact test | MA0156.1 | FEV | top 3760 seqs | 3.58e-15 | 1.905e-12 |
59. | Fisher-exact test | MA0087.1 | Sox5 | top 3760 seqs | 6.494e-15 | 3.455e-12 |
60. | Fisher-exact test | UP00042_2 | Gm397_secondary | top 3760 seqs | 2.268e-14 | 1.207e-11 |
61. | Fisher-exact test | UP00086_1 | Irf3_primary | top 3760 seqs | 2.775e-14 | 1.477e-11 |
62. | Fisher-exact test | MA0042.1 | FOXI1 | top 3760 seqs | 5.157e-14 | 2.743e-11 |
63. | Fisher-exact test | UP00073_2 | Foxa2_secondary | top 3760 seqs | 6.588e-14 | 3.505e-11 |
64. | Fisher-exact test | UP00023_1 | Sox30_primary | top 3760 seqs | 1.005e-13 | 5.346e-11 |
65. | Fisher-exact test | MA0137.2 | STAT1 | top 3760 seqs | 2.088e-13 | 1.111e-10 |
66. | Fisher-exact test | MA0019.1 | Ddit3::Cebpa | top 3760 seqs | 4.788e-13 | 2.547e-10 |
67. | Fisher-exact test | MA0080.2 | SPI1 | top 3760 seqs | 7.59e-13 | 4.038e-10 |
68. | Fisher-exact test | MA0164.1 | Nr2e3 | top 3760 seqs | 1.133e-12 | 6.027e-10 |
69. | Fisher-exact test | UP00075_1 | Sox15_primary | top 3760 seqs | 1.187e-12 | 6.313e-10 |
70. | Fisher-exact test | UP00007_1 | Egr1_primary | top 3760 seqs | 2.602e-12 | 1.384e-09 |
71. | Fisher-exact test | MA0033.1 | FOXL1 | top 3760 seqs | 3.108e-12 | 1.654e-09 |
72. | Fisher-exact test | UP00051_1 | Sox8_primary | top 3760 seqs | 4.1e-12 | 2.181e-09 |
73. | Fisher-exact test | UP00064_1 | Sox18_primary | top 3760 seqs | 7.304e-12 | 3.886e-09 |
74. | Fisher-exact test | MA0105.1 | NFKB1 | top 3760 seqs | 8.463e-12 | 4.502e-09 |
75. | Fisher-exact test | UP00006_2 | Zic3_secondary | top 3760 seqs | 8.709e-12 | 4.633e-09 |
76. | Fisher-exact test | MA0104.2 | Mycn | top 3760 seqs | 3.071e-11 | 1.634e-08 |
77. | Fisher-exact test | UP00041_1 | Foxj1_primary | top 3760 seqs | 3.957e-11 | 2.105e-08 |
78. | Fisher-exact test | UP00060_1 | Max_primary | top 3760 seqs | 5.121e-11 | 2.724e-08 |
79. | Fisher-exact test | UP00408_1 | Gabpa_primary | top 3760 seqs | 9.574e-11 | 5.093e-08 |
80. | Fisher-exact test | UP00255_1 | Dbx1_3486.1 | top 3760 seqs | 1.699e-10 | 9.038e-08 |
81. | Fisher-exact test | UP00071_1 | Sox21_primary | top 3760 seqs | 1.845e-10 | 9.814e-08 |
82. | Fisher-exact test | MA0055.1 | Myf | top 3760 seqs | 1.885e-10 | 1.003e-07 |
83. | Fisher-exact test | UP00129_1 | Pou3f1_3819.1 | top 3760 seqs | 2.057e-10 | 1.094e-07 |
84. | Fisher-exact test | MA0030.1 | FOXF2 | top 3760 seqs | 2.902e-10 | 1.544e-07 |
85. | Fisher-exact test | UP00094_2 | Zfp128_secondary | top 3760 seqs | 4.91e-10 | 2.612e-07 |
86. | Fisher-exact test | MA0152.1 | NFATC2 | top 3760 seqs | 1.017e-09 | 5.409e-07 |
87. | Fisher-exact test | UP00102_2 | Zic1_secondary | top 3760 seqs | 1.136e-09 | 6.042e-07 |
88. | Fisher-exact test | MA0116.1 | Zfp423 | top 3760 seqs | 1.333e-09 | 7.09e-07 |
89. | Fisher-exact test | UP00016_1 | Sry_primary | top 3760 seqs | 1.681e-09 | 8.943e-07 |
90. | Fisher-exact test | UP00254_1 | Pou2f1_3081.2 | top 3760 seqs | 1.905e-09 | 1.013e-06 |
91. | Fisher-exact test | MA0052.1 | MEF2A | top 3760 seqs | 4.244e-09 | 2.258e-06 |
92. | Fisher-exact test | UP00244_1 | Tlx2_3498.2 | top 3760 seqs | 4.295e-09 | 2.285e-06 |
93. | Fisher-exact test | MA0058.1 | MAX | top 3760 seqs | 4.352e-09 | 2.315e-06 |
94. | Fisher-exact test | UP00022_1 | Zfp740_primary | top 3760 seqs | 4.53e-09 | 2.41e-06 |
95. | Fisher-exact test | UP00165_1 | Titf1_1722.2 | top 3760 seqs | 4.601e-09 | 2.448e-06 |
96. | Fisher-exact test | UP00039_2 | Foxj3_secondary | top 3760 seqs | 6.728e-09 | 3.579e-06 |
97. | Fisher-exact test | UP00057_2 | Zic2_secondary | top 3760 seqs | 7.506e-09 | 3.993e-06 |
98. | Fisher-exact test | UP00158_1 | Pou1f1_3818.1 | top 3760 seqs | 8.454e-09 | 4.497e-06 |
99. | Fisher-exact test | MA0077.1 | SOX9 | top 3760 seqs | 9.395e-09 | 4.998e-06 |
100. | Fisher-exact test | UP00091_1 | Sox5_primary | top 3760 seqs | 9.969e-09 | 5.304e-06 |
101. | Fisher-exact test | UP00036_2 | Myf6_secondary | top 3760 seqs | 1.501e-08 | 7.984e-06 |
102. | Fisher-exact test | UP00105_1 | Pou3f4_3773.1 | top 3760 seqs | 2.1e-08 | 1.117e-05 |
103. | Fisher-exact test | MA0050.1 | IRF1 | top 3760 seqs | 2.231e-08 | 1.187e-05 |
104. | Fisher-exact test | UP00065_1 | Zfp161_primary | top 3760 seqs | 2.751e-08 | 1.464e-05 |
105. | Fisher-exact test | MA0259.1 | HIF1A::ARNT | top 3760 seqs | 2.869e-08 | 1.526e-05 |
106. | Fisher-exact test | MA0157.1 | FOXO3 | top 3760 seqs | 3.457e-08 | 1.839e-05 |
107. | Fisher-exact test | UP00149_1 | Phox2b_3948.1 | top 3760 seqs | 3.88e-08 | 2.064e-05 |
108. | Fisher-exact test | UP00028_2 | Tcfap2e_secondary | top 3760 seqs | 4.263e-08 | 2.268e-05 |
109. | Fisher-exact test | MA0090.1 | TEAD1 | top 3760 seqs | 4.405e-08 | 2.343e-05 |
110. | Fisher-exact test | MA0088.1 | znf143 | top 3760 seqs | 5.77e-08 | 3.07e-05 |
111. | Fisher-exact test | UP00088_1 | Plagl1_primary | top 3760 seqs | 7.356e-08 | 3.913e-05 |
112. | Fisher-exact test | UP00002_2 | Sp4_secondary | top 3760 seqs | 7.885e-08 | 4.195e-05 |
113. | Fisher-exact test | MA0081.1 | SPIB | top 3760 seqs | 9.636e-08 | 5.126e-05 |
114. | Fisher-exact test | UP00004_2 | Sox14_secondary | top 3760 seqs | 1.206e-07 | 6.418e-05 |
115. | Fisher-exact test | MA0160.1 | NR4A2 | top 3760 seqs | 1.33e-07 | 7.076e-05 |
116. | Fisher-exact test | MA0047.1 | Foxa2 | top 3760 seqs | 1.343e-07 | 7.147e-05 |
117. | Fisher-exact test | UP00406_1 | Spdef_primary | top 3760 seqs | 1.657e-07 | 8.815e-05 |
118. | Fisher-exact test | MA0078.1 | Sox17 | top 3760 seqs | 1.751e-07 | 9.317e-05 |
119. | Fisher-exact test | UP00118_1 | Pou4f3_2791.1 | top 3760 seqs | 2.079e-07 | 0.0001106 |
120. | Fisher-exact test | UP00047_2 | Zbtb7b_secondary | top 3760 seqs | 2.799e-07 | 0.0001489 |
121. | Fisher-exact test | MA0102.1 | Cebpa | top 3760 seqs | 3.19e-07 | 0.0001697 |
122. | Fisher-exact test | UP00249_1 | Nkx2-5_3436.1 | top 3760 seqs | 4.004e-07 | 0.000213 |
123. | Fisher-exact test | UP00029_2 | Tbp_secondary | top 3760 seqs | 6.384e-07 | 0.0003396 |
124. | Fisher-exact test | UP00172_1 | Prop1_3949.1 | top 3760 seqs | 7.064e-07 | 0.0003758 |
125. | Fisher-exact test | UP00046_1 | Tcfe2a_primary | top 3760 seqs | 1.042e-06 | 0.000554 |
126. | Fisher-exact test | MA0002.2 | RUNX1 | top 3760 seqs | 1.235e-06 | 0.000657 |
127. | Fisher-exact test | MA0108.1 | TBP | top 3760 seqs | 1.308e-06 | 0.0006958 |
128. | Fisher-exact test | UP00050_1 | Bhlhb2_primary | top 3760 seqs | 1.312e-06 | 0.0006977 |
129. | Fisher-exact test | MA0102.2 | CEBPA | top 3760 seqs | 1.447e-06 | 0.0007696 |
130. | Fisher-exact test | MA0070.1 | PBX1 | top 3760 seqs | 1.613e-06 | 0.000858 |