TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Alt. Name 

Preview 

Matches 

List 

GGCCTNB 7.5e-362
GGCCTGG
1 MA0146.1 (Zfx)
GGAAR 3.7e-047
GGAAG
9 MA0144.1 (Stat3) , Ehf_primary, Elf3_primary, Gabpa_primary, MA0156.1 (FEV) , MA0076.1 (ELK4) , MA0080.2 (SPI1) , MA0028.1 (ELK1) , MA0062.2 (GABPA)
AGGCCYD 1.5e-025
AGGCCCA
0
ATGGCG 1.2e-024
ATGGCG
0
CACGTG 2.5e-023
CACGTG
10 MA0093.1 (USF1) , MA0058.1 (MAX) , MA0104.1 (Mycn) , MA0059.1 (MYC::MAX) , Max_primary, Bhlhb2_primary, Bhlhb2_secondary, MA0004.1 (Arnt) , MA0147.1 (Myc) , MA0104.2 (Mycn)
AMACAVA 4.6e-015
ACACAGA
0
CSGGGAM 3.8e-014
CGGGGAC
0
CHGGGCC 1.5e-011
CTGGGCC
0
AKRAA 5.5e-011
AGAAA
0
CGGARCC 6.6e-009
CGGAGCC
0
CDCCKCC 3.5e-008
CGCCGCC
0
AKGTRA 1.1e-007
AGGTGA
1 MA0103.1 (ZEB1)
AGGAYG 1.7e-005
AGGATG
0
TTCCCR 1.1e-003
TTCCCA
0
ACKGTG 3.3e-003
ACTGTG
0
CHGCAGC 3.9e-003
CAGCAGC
0
AAGGTCA 3.9e-003
AAGGTCA
10 MA0141.1 (Esrrb) , MA0115.1 (NR1H2::RXRA) , MA0065.1 (PPARG::RXRA) , Rara_primary, Esrra_primary, Nr2f2_primary, MA0160.1 (NR4A2) , MA0071.1 (RORA_1) , MA0017.1 (NR2F1) , MA0065.2 (PPARG::RXRA)
CACASCC 8.6e-003
CACAGCC
0
GGCCTR 1.3e-002
GGCCTG
1 MA0146.1 (Zfx)

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

jaspar_vertebrates.meme 146 22
uniprobe_mouse.meme 386 9

Matches to Query: GGCCTNB (7.5e-362)

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Summary 

Alignment 

Name MA0146.1
Alt. Name Zfx
Database jaspar_vertebrates.meme
p-value 5.62439e-07
E-value 0.000299218
q-value 0.000598435
Overlap 6
Offset 8
Orientation Normal
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Matches to Query: GGAAR (3.7e-047)

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Summary 

Alignment 

Name MA0144.1
Alt. Name Stat3
Database jaspar_vertebrates.meme
p-value 5.70796e-07
E-value 0.000303663
q-value 0.000597184
Overlap 5
Offset 5
Orientation Normal
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Summary 

Alignment 

Name Ehf_primary
Database uniprobe_mouse.meme
p-value 7.564e-06
E-value 0.00402405
q-value 0.00331659
Overlap 5
Offset 7
Orientation Normal
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Summary 

Alignment 

Name Elf3_primary
Database uniprobe_mouse.meme
p-value 1.09253e-05
E-value 0.00581224
q-value 0.00331659
Overlap 5
Offset 5
Orientation Normal
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Summary 

Alignment 

Name Gabpa_primary
Database uniprobe_mouse.meme
p-value 1.57809e-05
E-value 0.00839545
q-value 0.00331659
Overlap 5
Offset 7
Orientation Normal
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Summary 

Alignment 

Name MA0156.1
Alt. Name FEV
Database jaspar_vertebrates.meme
p-value 1.64101e-05
E-value 0.00873017
q-value 0.00331659
Overlap 5
Offset 2
Orientation Normal
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Summary 

Alignment 

Name MA0076.1
Alt. Name ELK4
Database jaspar_vertebrates.meme
p-value 2.05126e-05
E-value 0.0109127
q-value 0.00331659
Overlap 5
Offset 3
Orientation Normal
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Summary 

Alignment 

Name MA0080.2
Alt. Name SPI1
Database jaspar_vertebrates.meme
p-value 2.21903e-05
E-value 0.0118052
q-value 0.00331659
Overlap 5
Offset 1
Orientation Normal
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Summary 

Alignment 

Name MA0028.1
Alt. Name ELK1
Database jaspar_vertebrates.meme
p-value 3.36413e-05
E-value 0.0178972
q-value 0.00439957
Overlap 5
Offset 5
Orientation Normal
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Summary 

Alignment 

Name MA0062.2
Alt. Name GABPA
Database jaspar_vertebrates.meme
p-value 5.17773e-05
E-value 0.0275455
q-value 0.006019
Overlap 5
Offset 2
Orientation Normal
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Matches to Query: AGGCCYD (1.5e-025)

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Matches to Query: ATGGCG (1.2e-024)

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Matches to Query: CACGTG (2.5e-023)

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Summary 

Alignment 

Name MA0093.1
Alt. Name USF1
Database jaspar_vertebrates.meme
p-value 3.89986e-07
E-value 0.000207473
q-value 0.00010171
Overlap 6
Offset 0
Orientation Normal
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Summary 

Alignment 

Name MA0058.1
Alt. Name MAX
Database jaspar_vertebrates.meme
p-value 6.82476e-07
E-value 0.000363077
q-value 0.00010171
Overlap 6
Offset 3
Orientation Normal
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Summary 

Alignment 

Name MA0104.1
Alt. Name Mycn
Database jaspar_vertebrates.meme
p-value 7.75444e-07
E-value 0.000412536
q-value 0.00010171
Overlap 6
Offset 0
Orientation Normal
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Summary 

Alignment 

Name MA0059.1
Alt. Name MYC::MAX
Database jaspar_vertebrates.meme
p-value 7.79972e-07
E-value 0.000414945
q-value 0.00010171
Overlap 6
Offset 3
Orientation Normal
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Summary 

Alignment 

Name Max_primary
Database uniprobe_mouse.meme
p-value 1.26745e-06
E-value 0.000674286
q-value 0.000129866
Overlap 6
Offset 4
Orientation Normal
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Summary 

Alignment 

Name Bhlhb2_primary
Database uniprobe_mouse.meme
p-value 1.85243e-06
E-value 0.000985495
q-value 0.000129866
Overlap 6
Offset 8
Orientation Normal
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Summary 

Alignment 

Name Bhlhb2_secondary
Database uniprobe_mouse.meme
p-value 1.94993e-06
E-value 0.00103736
q-value 0.000129866
Overlap 6
Offset 8
Orientation Normal
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Summary 

Alignment 

Name MA0004.1
Alt. Name Arnt
Database jaspar_vertebrates.meme
p-value 1.99178e-06
E-value 0.00105963
q-value 0.000129866
Overlap 6
Offset 0
Orientation Normal
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Summary 

Alignment 

Name MA0147.1
Alt. Name Myc
Database jaspar_vertebrates.meme
p-value 4.64749e-06
E-value 0.00247247
q-value 0.000269352
Overlap 6
Offset 2
Orientation Reverse Complement
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Summary 

Alignment 

Name MA0104.2
Alt. Name Mycn
Database jaspar_vertebrates.meme
p-value 7.83326e-06
E-value 0.00416729
q-value 0.000408589
Overlap 6
Offset 2
Orientation Reverse Complement
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Matches to Query: AMACAVA (4.6e-015)

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Matches to Query: CSGGGAM (3.8e-014)

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Matches to Query: CHGGGCC (1.5e-011)

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Matches to Query: AKRAA (5.5e-011)

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Matches to Query: CGGARCC (6.6e-009)

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Matches to Query: CDCCKCC (3.5e-008)

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Matches to Query: AKGTRA (1.1e-007)

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Summary 

Alignment 

Name MA0103.1
Alt. Name ZEB1
Database jaspar_vertebrates.meme
p-value 2.56268e-05
E-value 0.0136335
q-value 0.0272669
Overlap 5
Offset 1
Orientation Reverse Complement
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Matches to Query: AGGAYG (1.7e-005)

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Matches to Query: TTCCCR (1.1e-003)

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Matches to Query: ACKGTG (3.3e-003)

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Matches to Query: CHGCAGC (3.9e-003)

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Matches to Query: AAGGTCA (3.9e-003)

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Summary 

Alignment 

Name MA0141.1
Alt. Name Esrrb
Database jaspar_vertebrates.meme
p-value 1.60179e-07
E-value 8.52154e-05
q-value 0.000100647
Overlap 7
Offset 5
Orientation Normal
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Summary 

Alignment 

Name MA0115.1
Alt. Name NR1H2::RXRA
Database jaspar_vertebrates.meme
p-value 2.40269e-07
E-value 0.000127823
q-value 0.000100647
Overlap 7
Offset 8
Orientation Normal
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Summary 

Alignment 

Name MA0065.1
Alt. Name PPARG::RXRA
Database jaspar_vertebrates.meme
p-value 2.88323e-07
E-value 0.000153388
q-value 0.000100647
Overlap 7
Offset 10
Orientation Normal
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Summary 

Alignment 

Name Rara_primary
Database uniprobe_mouse.meme
p-value 1.73894e-06
E-value 0.000925114
q-value 0.000390231
Overlap 7
Offset 5
Orientation Normal
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Summary 

Alignment 

Name Esrra_primary
Database uniprobe_mouse.meme
p-value 1.86315e-06
E-value 0.000991193
q-value 0.000390231
Overlap 7
Offset 5
Orientation Normal
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Summary 

Alignment 

Name Nr2f2_primary
Database uniprobe_mouse.meme
p-value 3.13431e-06
E-value 0.00166745
q-value 0.00054706
Overlap 7
Offset 5
Orientation Normal
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Summary 

Alignment 

Name MA0160.1
Alt. Name NR4A2
Database jaspar_vertebrates.meme
p-value 6.93074e-06
E-value 0.00368715
q-value 0.00103687
Overlap 7
Offset 0
Orientation Normal
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Summary 

Alignment 

Name MA0071.1
Alt. Name RORA_1
Database jaspar_vertebrates.meme
p-value 1.95905e-05
E-value 0.0104222
q-value 0.00256449
Overlap 7
Offset 3
Orientation Normal
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Summary 

Alignment 

Name MA0017.1
Alt. Name NR2F1
Database jaspar_vertebrates.meme
p-value 5.60188e-05
E-value 0.029802
q-value 0.00651833
Overlap 7
Offset 7
Orientation Reverse Complement
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Summary 

Alignment 

Name MA0065.2
Alt. Name PPARG::RXRA
Database jaspar_vertebrates.meme
p-value 8.81085e-05
E-value 0.0468737
q-value 0.00922704
Overlap 7
Offset 8
Orientation Normal
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Matches to Query: CACASCC (8.6e-003)

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Matches to Query: GGCCTR (1.3e-002)

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Summary 

Alignment 

Name MA0146.1
Alt. Name Zfx
Database jaspar_vertebrates.meme
p-value 1.58582e-05
E-value 0.00843657
q-value 0.0168731
Overlap 6
Offset 8
Orientation Normal
Create custom LOGO ↧  [Query Top]
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TOMTOM version
4.5.0 (Release date: Wed Oct 20 15:18:53 EST 2010)
Reference
Shobhit Gupta, John A. Stamatoyannopoulos, Timothy L. Bailey and William Stafford Noble, "Quantifying similarity between motifs",
Genome Biology, 8:R24, 2007
Command line summary

Background letter frequencies (from first motif database):
A: 0.250   C: 0.250   G: 0.250   T: 0.250

Result calculation took 7.740 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.