TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Alt. Name 

Preview 

Matches 

List 

ATGBWAA 2.8e-126
ATGCAAA
4 Pou2f3_3986.2, Pou2f2_3748.1, MA0142.1 (Pou5f1) , MA0143.1 (Sox2)
ACAAWRG 2.6e-049
ACAAAGG
6 MA0143.1 (Sox2) , Sox11_primary, MA0442.1 (SOX10) , Sox4_primary, MA0142.1 (Pou5f1) , Sox14_secondary
WTATGCR 9.0e-045
ATATGCA
1 Pou3f3_3235.2
GGGHGGR 2.3e-027
GGGAGGG
6 MA0079.2 (SP1) , Sox13_secondary, Bcl6b_secondary, Ascl2_secondary, Zfp410_secondary, MA0039.2 (Klf4)
TTCCKGB 1.0e-019
TTCCTGC
2 MA0156.1 (FEV) , MA0080.2 (SPI1)
ACAAWGM 4.3e-016
ACAAAGA
1 MA0442.1 (SOX10)
ATGMATA 3.4e-010
ATGAATA
0
RGRAA 1.3e-007
AGGAA
0
GTCACS 6.3e-005
GTCACC
1 MA0018.1 (CREB1)
ATGCAGA 7.4e-005
ATGCAGA
0
ATGCGCA 1.7e-004
ATGCGCA
0
TGAATR 2.3e-004
TGAATG
2 Sox8_secondary, Sox17_secondary
CGGARCC 9.0e-003
CGGAGCC
0
CGGRAG 1.2e-002
CGGGAG
0
AAGGTCA 4.4e-002
AAGGTCA
10 MA0141.1 (Esrrb) , MA0115.1 (NR1H2::RXRA) , MA0065.1 (PPARG::RXRA) , Rara_primary, Esrra_primary, Nr2f2_primary, MA0160.1 (NR4A2) , MA0071.1 (RORA_1) , MA0017.1 (NR2F1) , MA0065.2 (PPARG::RXRA)
CACGCCC 4.7e-002
CACGCCC
3 Klf7_primary, Sp4_primary, MA0039.2 (Klf4)

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

jaspar_vertebrates.meme 146 15
uniprobe_mouse.meme 386 17

Matches to Query: ATGBWAA (2.8e-126)

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Summary 

Alignment 

Name Pou2f3_3986.2
Database uniprobe_mouse.meme
p-value 9.06946e-08
E-value 4.82495e-05
q-value 9.64991e-05
Overlap 7
Offset 4
Orientation Normal
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Summary 

Alignment 

Name Pou2f2_3748.1
Database uniprobe_mouse.meme
p-value 1.88917e-07
E-value 0.000100504
q-value 0.000100504
Overlap 7
Offset 4
Orientation Normal
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Summary 

Alignment 

Name MA0142.1
Alt. Name Pou5f1
Database jaspar_vertebrates.meme
p-value 1.0129e-06
E-value 0.000538865
q-value 0.000359243
Overlap 7
Offset 7
Orientation Normal
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Summary 

Alignment 

Name MA0143.1
Alt. Name Sox2
Database jaspar_vertebrates.meme
p-value 5.85105e-05
E-value 0.0311276
q-value 0.0155638
Overlap 7
Offset 8
Orientation Normal
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Matches to Query: ACAAWRG (2.6e-049)

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Summary 

Alignment 

Name MA0143.1
Alt. Name Sox2
Database jaspar_vertebrates.meme
p-value 1.27206e-06
E-value 0.000676737
q-value 0.00133215
Overlap 7
Offset 8
Orientation Reverse Complement
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Summary 

Alignment 

Name Sox11_primary
Database uniprobe_mouse.meme
p-value 9.08262e-06
E-value 0.00483196
q-value 0.00402709
Overlap 7
Offset 6
Orientation Normal
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Summary 

Alignment 

Name MA0442.1
Alt. Name SOX10
Database jaspar_vertebrates.meme
p-value 1.16629e-05
E-value 0.00620464
q-value 0.00402709
Overlap 6
Offset 0
Orientation Reverse Complement
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Summary 

Alignment 

Name Sox4_primary
Database uniprobe_mouse.meme
p-value 1.53818e-05
E-value 0.00818312
q-value 0.00402709
Overlap 7
Offset 6
Orientation Normal
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Summary 

Alignment 

Name MA0142.1
Alt. Name Pou5f1
Database jaspar_vertebrates.meme
p-value 8.5917e-05
E-value 0.0457079
q-value 0.0156785
Overlap 6
Offset 9
Orientation Reverse Complement
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Summary 

Alignment 

Name Sox14_secondary
Database uniprobe_mouse.meme
p-value 8.98279e-05
E-value 0.0477884
q-value 0.0156785
Overlap 7
Offset 5
Orientation Normal
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Matches to Query: WTATGCR (9.0e-045)

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Summary 

Alignment 

Name Pou3f3_3235.2
Database uniprobe_mouse.meme
p-value 4.85042e-06
E-value 0.00258042
q-value 0.00515753
Overlap 7
Offset 4
Orientation Reverse Complement
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Matches to Query: GGGHGGR (2.3e-027)

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Summary 

Alignment 

Name MA0079.2
Alt. Name SP1
Database jaspar_vertebrates.meme
p-value 5.75044e-06
E-value 0.00305923
q-value 0.0056782
Overlap 7
Offset 2
Orientation Reverse Complement
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Summary 

Alignment 

Name Sox13_secondary
Database uniprobe_mouse.meme
p-value 1.07821e-05
E-value 0.00573606
q-value 0.0056782
Overlap 7
Offset 5
Orientation Normal
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Summary 

Alignment 

Name Bcl6b_secondary
Database uniprobe_mouse.meme
p-value 1.77844e-05
E-value 0.00946128
q-value 0.00624389
Overlap 7
Offset 6
Orientation Reverse Complement
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Summary 

Alignment 

Name Ascl2_secondary
Database uniprobe_mouse.meme
p-value 3.91239e-05
E-value 0.0208139
q-value 0.00846324
Overlap 7
Offset 4
Orientation Reverse Complement
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Summary 

Alignment 

Name Zfp410_secondary
Database uniprobe_mouse.meme
p-value 4.59073e-05
E-value 0.0244227
q-value 0.00846324
Overlap 7
Offset 6
Orientation Reverse Complement
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Summary 

Alignment 

Name MA0039.2
Alt. Name Klf4
Database jaspar_vertebrates.meme
p-value 4.82114e-05
E-value 0.0256485
q-value 0.00846324
Overlap 7
Offset 1
Orientation Normal
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Matches to Query: TTCCKGB (1.0e-019)

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Summary 

Alignment 

Name MA0156.1
Alt. Name FEV
Database jaspar_vertebrates.meme
p-value 8.80273e-07
E-value 0.000468305
q-value 0.000925393
Overlap 6
Offset 2
Orientation Reverse Complement
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Summary 

Alignment 

Name MA0080.2
Alt. Name SPI1
Database jaspar_vertebrates.meme
p-value 6.24318e-05
E-value 0.0332137
q-value 0.0328159
Overlap 5
Offset 2
Orientation Reverse Complement
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Matches to Query: ACAAWGM (4.3e-016)

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Summary 

Alignment 

Name MA0442.1
Alt. Name SOX10
Database jaspar_vertebrates.meme
p-value 3.45109e-06
E-value 0.00183598
q-value 0.00364185
Overlap 6
Offset 0
Orientation Reverse Complement
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Matches to Query: ATGMATA (3.4e-010)

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Matches to Query: RGRAA (1.3e-007)

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Matches to Query: GTCACS (6.3e-005)

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Summary 

Alignment 

Name MA0018.1
Alt. Name CREB1
Database jaspar_vertebrates.meme
p-value 8.60292e-05
E-value 0.0457675
q-value 0.0359502
Overlap 6
Offset 3
Orientation Reverse Complement
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Matches to Query: ATGCAGA (7.4e-005)

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Matches to Query: ATGCGCA (1.7e-004)

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Matches to Query: TGAATR (2.3e-004)

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Summary 

Alignment 

Name Sox8_secondary
Database uniprobe_mouse.meme
p-value 2.44866e-05
E-value 0.0130269
q-value 0.025926
Overlap 6
Offset 7
Orientation Reverse Complement
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Summary 

Alignment 

Name Sox17_secondary
Database uniprobe_mouse.meme
p-value 4.8733e-05
E-value 0.025926
q-value 0.025926
Overlap 6
Offset 6
Orientation Reverse Complement
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Matches to Query: CGGARCC (9.0e-003)

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Matches to Query: CGGRAG (1.2e-002)

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Matches to Query: AAGGTCA (4.4e-002)

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Summary 

Alignment 

Name MA0141.1
Alt. Name Esrrb
Database jaspar_vertebrates.meme
p-value 1.60179e-07
E-value 8.52154e-05
q-value 0.000100647
Overlap 7
Offset 5
Orientation Normal
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Summary 

Alignment 

Name MA0115.1
Alt. Name NR1H2::RXRA
Database jaspar_vertebrates.meme
p-value 2.40269e-07
E-value 0.000127823
q-value 0.000100647
Overlap 7
Offset 8
Orientation Normal
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Summary 

Alignment 

Name MA0065.1
Alt. Name PPARG::RXRA
Database jaspar_vertebrates.meme
p-value 2.88323e-07
E-value 0.000153388
q-value 0.000100647
Overlap 7
Offset 10
Orientation Normal
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Summary 

Alignment 

Name Rara_primary
Database uniprobe_mouse.meme
p-value 1.73894e-06
E-value 0.000925114
q-value 0.000390231
Overlap 7
Offset 5
Orientation Normal
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Summary 

Alignment 

Name Esrra_primary
Database uniprobe_mouse.meme
p-value 1.86315e-06
E-value 0.000991193
q-value 0.000390231
Overlap 7
Offset 5
Orientation Normal
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Summary 

Alignment 

Name Nr2f2_primary
Database uniprobe_mouse.meme
p-value 3.13431e-06
E-value 0.00166745
q-value 0.00054706
Overlap 7
Offset 5
Orientation Normal
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Summary 

Alignment 

Name MA0160.1
Alt. Name NR4A2
Database jaspar_vertebrates.meme
p-value 6.93074e-06
E-value 0.00368715
q-value 0.00103687
Overlap 7
Offset 0
Orientation Normal
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Summary 

Alignment 

Name MA0071.1
Alt. Name RORA_1
Database jaspar_vertebrates.meme
p-value 1.95905e-05
E-value 0.0104222
q-value 0.00256449
Overlap 7
Offset 3
Orientation Normal
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Summary 

Alignment 

Name MA0017.1
Alt. Name NR2F1
Database jaspar_vertebrates.meme
p-value 5.60188e-05
E-value 0.029802
q-value 0.00651833
Overlap 7
Offset 7
Orientation Reverse Complement
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Summary 

Alignment 

Name MA0065.2
Alt. Name PPARG::RXRA
Database jaspar_vertebrates.meme
p-value 8.81085e-05
E-value 0.0468737
q-value 0.00922704
Overlap 7
Offset 8
Orientation Normal
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Matches to Query: CACGCCC (4.7e-002)

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Summary 

Alignment 

Name Klf7_primary
Database uniprobe_mouse.meme
p-value 3.71228e-05
E-value 0.0197493
q-value 0.0270092
Overlap 7
Offset 5
Orientation Normal
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Summary 

Alignment 

Name Sp4_primary
Database uniprobe_mouse.meme
p-value 6.81952e-05
E-value 0.0362798
q-value 0.0270092
Overlap 7
Offset 3
Orientation Normal
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Summary 

Alignment 

Name MA0039.2
Alt. Name Klf4
Database jaspar_vertebrates.meme
p-value 7.72246e-05
E-value 0.0410835
q-value 0.0270092
Overlap 7
Offset 2
Orientation Reverse Complement
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TOMTOM version
4.5.0 (Release date: Wed Oct 20 15:18:53 EST 2010)
Reference
Shobhit Gupta, John A. Stamatoyannopoulos, Timothy L. Bailey and William Stafford Noble, "Quantifying similarity between motifs",
Genome Biology, 8:R24, 2007
Command line summary

Background letter frequencies (from first motif database):
A: 0.250   C: 0.250   G: 0.250   T: 0.250

Result calculation took 7.236 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.